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Synthesis and biological properties of new 1 beta-methylcarbapenems having tetrazolothioether moiety

Authors
Shin, KJ; Koo, KD; Yoo, KH; Kim, DC; Kim, DJ; Park, SW
Issue Date
2000-07-03
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.10, no.13, pp.1421 - 1425
Abstract
The synthesis and biological activities of a series of new 1 beta-methylcarbapenems 1a-l having tetrazolothioether moiety at C-5 position of pyrrolidine were described. Among these compounds, 1c showed the most potent antibacterial activity and advanced pharmacokinetics compared with imipenem and meropenem. (C) 2000 Elsevier Science Ltd. All rights reserved.
Keywords
CARBAPENEMS; DERIVATIVES; THIENAMYCIN; C-2; CARBAPENEMS; DERIVATIVES; THIENAMYCIN; C-2; 1β-methylcarbapenems; tetrazolothioether moiety; synthesis; biological properties
ISSN
0960-894X
URI
https://pubs.kist.re.kr/handle/201004/141238
DOI
10.1016/S0960-894X(00)00253-5
Appears in Collections:
KIST Article > 2000
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