Synthesis and antibacterial activity of new carbapenems containing isoxazole moiety

Abstract

The synthesis and biological activity of a series of new 1 beta-methylcarbapenems 1a-g containing 5'-isoxazolopyrrolidin-3'-ylthio derivatives as C-2 side chain are described. Most compounds exhibited potent and well-balanced antibacterial activity as well as high stability to DHP-1 comparable to that of meropenem. 1e and 1c showed the best combination of antibacterial activity and stability to DHP-1, respectively. (C) 2000 Elsevier Science Ltd. All rights reserved.