Binding affinities of 3-(3-phenylisoxazol-5-YL)methylidene-1-azabicycles to acetylcholine receptors

Abstract

A series of 3-(3-phenylisoxazol-5-yl)methylidene-1-azabicycles synthesized showed different binding characteristics to acetylcholine receptors depending on the substituents on the phenyl ring. Small polar substituents gave preferential binding affinity to nicotinic receptors, and large hydrophobic substituents to muscarinic receptors. (C) 1999 Elsevier Science Ltd. All rights reserved.