Synthesis and activity as a glycosidase inhibitor of 2,8-dihydroxyindolizidines

Abstract

The synthesis and enzyme assay of 2,8-dihydroxyindolizidines (5) were described. Four diastereomers of these were prepared from trans-4-hydroxy-L-proline (6) which is commercially available amino acid. Among synthetic compounds 5a(1) and 5b(2) showed medium potent inhibition to alpha-amyloglycosidase, while 5a(2) displayed medium activity to alpha-glucosidase.