Preparation of biodegradable microspheres containing water-soluble drug, beta-lactam antibiotic

Authors
Kim, JHKwon, ICKim, YHLa, SBSohn, YTJeong, SY
Issue Date
1996-02
Publisher
PHARMACEUTICAL SOCIETY KOREA
Citation
ARCHIVES OF PHARMACAL RESEARCH, v.19, no.1, pp.30 - 35
Abstract
Poly (l-lactic) (PLLA) microspheres loaded with ampicillin sodium (AMP-Na), beta-lactam antibiotic, were prepared by a w/o/w multiple emulsion-solvent evaporation method. The amounts of each component in three phases (inner water phase, organic phase, and outer water phase) were carefully examined in the preparation of PLLA microspheres. The stirring rate, another preparation parameter, was also investigated for study on the effect of mechanical stress on the drug loading and morphology of PLLA microspheres. Most of the preparation parameters had a great influence on the drug loading, surface morphology and size distribution of PLLA microspheres. PLLA microspheres with 15.89 w/w% drug loading were subjected to the in vitro release experiment. The release of ampicillin sodium was constant at a rate of 1.68 mu g/ml/day per 1 mg of microspheres for 18 days after a 4 days initial burst effect.
Keywords
LOADED POLY(D,L-LACTIDE) MICROSPHERES; SOLVENT EVAPORATION; MICROCAPSULES; ACID; LOADED POLY(D,L-LACTIDE) MICROSPHERES; SOLVENT EVAPORATION; MICROCAPSULES; ACID; poly (l-lactic acid); microspheres; (w/o/w) Emulsion; solvent evaporation; ampicillin sodium; antibiotics
ISSN
0253-6269
URI
https://pubs.kist.re.kr/handle/201004/144550
DOI
10.1007/BF02976816
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KIST Article > Others
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