Thermo-responsive hydrogel via sustained Co-delivery of TA and PDGF to modulate the diabetic microenvironment and accelerate diabetic wound healing

Authors
Kim, JisunBong, Ki WanCho, Jung-KyoSong, Soo-Chang
Issue Date
2025-06
Publisher
Royal Society of Chemistry
Citation
Journal of Materials Chemistry B, v.13, no.24, pp.7090 - 7105
Abstract
In modern society, the need for diabetic wound healing is increasing due to the increase in the number of diabetic patients. In particular, chronic inflammation is a major problem in diabetic wounds due to excessive accumulation of reactive oxygen species (ROS). Therefore, it is essential to remove ROS and promote angiogenesis for effective diabetic wound healing. In this study, we developed a thermo-responsive poly(organophosphazene) hydrogel system (TSP-TP) designed to deliver antioxidants and growth factors for a long period of time. The TSP-TP hydrogel stably loads and continuously releases tannic acid (TA) and platelet-derived growth factor (PDGF) through various physical interactions. Effective ROS scavenging induced macrophage polarization and alleviated chronic inflammation, while the sustained release of PDGF promoted angiogenesis, ultimately maximizing wound healing efficacy in a diabetic mouse model. Based on these results, the proposed TSP-TP hydrogel demonstrates synergistic effects through sustained delivery of antioxidants and growth factors, demonstrating a promising system with high applicability in diabetic wound treatment.
Keywords
DRUG-RELEASE; REGENERATION; INFLAMMATION; ANTIOXIDANT; MACROPHAGES; SCAFFOLDS; BOND; TANNIC-ACID; GROWTH-FACTOR
ISSN
2050-750X
URI
https://pubs.kist.re.kr/handle/201004/152695
DOI
10.1039/d5tb00563a
Appears in Collections:
KIST Article > Others
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE