Synthesis of styrylbenzofuran derivatives as styrylquinoline analogues for HIV-1 integrase inhibitor
- Authors
- Yoo, H.; Lee, J.Y.; Park, J.H.; Chung, B.Y.; Lee, Y.S.
- Issue Date
- 2003-12
- Publisher
- Elsevier Masson SAS
- Citation
- Farmaco, v.58, no.12, pp.1243 - 1250
- Abstract
- A series of styrylbenzofuran derivatives (8a-i) as styrylquinoline isosters were efficiently prepared by Wittig reaction and evaluated for inhibitory activity against HIV-1 integrase. In this series, compounds 8g, 8h and 8i containing a free catechol ring showed moderate inhibitory activities (IC50=∼40 μM) against HIV-1 integrase, while less than the corresponding styrylquinoline compound (I). ？ 2003 ？ditions scientifiques et m？dicales Elsevier SAS. All rights reserved.
- Keywords
- 7 hydroxy 2 [2 (3,4 dihydroxyphenyl)ethenyl] 6 benzofuran carboxylic acid; 7 hydroxy 2 [2 (4 hydroxyphenyl)ethynyl] 6 benzofuran carboxylic acid; 7 methoxy 2 [2 (4 hydroxyphenyl)ethenyl] 6 benzofuran carboxylic acid; benzofuran derivative; integrase inhibitor; methyl 7 hydroxy 2 [2 (3,4 dihydroxyphenyl)ethenyl] 6 benzofuran carboxylate; methyl 7 hydroxy 2 [2 (4 hydroxyphenyl)ethenyl] 6 benzofuran carboxylate; methyl 7 methoxy 2 [2 (3,4 dihydroxyphenyl)ethenyl] 6 benzofuran carboxylate; methyl 7 methoxy 2 [2 (3,4 dimethoxyphenyl)ethenyl] 6 benzofuran carboxylate; methyl 7 methoxy 2 [2 (4 hydroxyphenyl)ethenyl] 6 benzofuran carboxylate; methyl 7 methoxy 2 [2 (4 methoxyphenyl)ethenyl] 6 benzofuran carboxylate; quinoline derivative; unclassified drug; article; drug activity; drug screening; drug structure; drug synthesis; enzyme inhibition; Human immunodeficiency virus 1; IC 50; nonhuman; Wittig reaction; 7 hydroxy 2 [2 (3,4 dihydroxyphenyl)ethenyl] 6 benzofuran carboxylic acid; 7 hydroxy 2 [2 (4 hydroxyphenyl)ethynyl] 6 benzofuran carboxylic acid; 7 methoxy 2 [2 (4 hydroxyphenyl)ethenyl] 6 benzofuran carboxylic acid; benzofuran derivative; integrase inhibitor; methyl 7 hydroxy 2 [2 (3,4 dihydroxyphenyl)ethenyl] 6 benzofuran carboxylate; methyl 7 hydroxy 2 [2 (4 hydroxyphenyl)ethenyl] 6 benzofuran carboxylate; methyl 7 methoxy 2 [2 (3,4 dihydroxyphenyl)ethenyl] 6 benzofuran carboxylate; methyl 7 methoxy 2 [2 (3,4 dimethoxyphenyl)ethenyl] 6 benzofuran carboxylate; methyl 7 methoxy 2 [2 (4 hydroxyphenyl)ethenyl] 6 benzofuran carboxylate; methyl 7 methoxy 2 [2 (4 methoxyphenyl)ethenyl] 6 benzofuran carboxylate; quinoline derivative; unclassified drug; article; drug activity; drug screening; drug structure; drug synthesis; enzyme inhibition; Human immunodeficiency virus 1; IC 50; nonhuman; Wittig reaction; AIDS; HIV; Integrase inhibitor; Styrylbenzofuran; Wittig reaction
- ISSN
- 0014-827X
- Appears in Collections:
- KIST Article > 2003
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