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QSAR study of quinolinediones with inhibitory activity of endothelium-dependent vasorelaxation by CoMSIA

Authors
Choo, HYP; Choi, S; Ryu, CK; Kim, HJ; Lee, IY; Pae, AN; Koh, HY
Issue Date
2003-05-01
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
BIOORGANIC & MEDICINAL CHEMISTRY, v.11, no.9, pp.2019 - 2023
Abstract
The 3D-QSAR study of quinolinediones which showed potent inhibitory effect on the acetylcholine induced vaso-relaxation of rat aorta with the endothelium was conducted by CoMSIA. The statistical result, cross-validated q(2) (0.741) and r(2) (0.960) values, gave reliability to the prediction of inhibitory activity of this series. (C) 2003 Elsevier Science Ltd. All rights reserved.
Keywords
NITRIC-OXIDE SYNTHASE; POTENT INHIBITORS; LY83583; NITRIC-OXIDE SYNTHASE; POTENT INHIBITORS; LY83583; QSAR; quinolinedione; CoMSIA
ISSN
0968-0896
URI
https://pubs.kist.re.kr/handle/201004/138583
DOI
10.1016/S0968-0896(03)00045-2
Appears in Collections:
KIST Article > 2003
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