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Epoxyalkanoyls as novel ACE inhibitors

Authors
Choo, HYP; Yoon, HR; Park, HS; Kim, DH; Park, J; Kim, J
Issue Date
1998-04
Publisher
PHARMACEUTICAL SOCIETY KOREA
Citation
ARCHIVES OF PHARMACAL RESEARCH, v.21, no.2, pp.168 - 173
Abstract
The epoxyalkanoyl derivatives were designed and synthesized as ACE inhibitors. Coupling of unsaturated carboxylic acids with amino acids and following epoxidation with dimethyldioxirane gave the epoxyalkanoyls with high yield. The inhibitory activity of synthesized compounds on angiotensin converting enzyme was IC50 values of 0.06 similar to 5.5 mu M.
Keywords
ANGIOTENSIN-CONVERTING ENZYME; ANTIHYPERTENSIVE AGENTS; DESIGN; ACIDS; ANGIOTENSIN-CONVERTING ENZYME; ANTIHYPERTENSIVE AGENTS; DESIGN; ACIDS; epoxides; angiotensin converting enzyme inhibitor; irreversible inhibition
ISSN
0253-6269
URI
https://pubs.kist.re.kr/handle/201004/143157
DOI
10.1007/BF02974023
Appears in Collections:
KIST Article > Others
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